Orellanine or orellanin is a mycotoxin found in a group of mushrooms known as the Orellani within the family Cortinariaceae. [1] Structurally, it is a bipyridine N-oxide compound somewhat …

Fungal metabolites represent an underutilized resource in the development of novel anticancer drugs. This review will focus on the promising fungal nephrotoxin orellanine, found in …

Orellanine or Orellanin is a pyridine N-oxide and a crystalline alkaloid that is found naturally in some lifeforms, specifically certain fungi. It has been found in at least 34 types of mushrooms …

Nov 9, 2015 · Orellanine is a nephrotoxic toxin produced by some mushroom species of the Cortinarius genus, typically found in Europe and North America. The nephrotoxicity of …

Mar 18, 2025 · The study will evaluate the investigational drug product ONC175 (orellanine) in patients with metastatic clear cell or papillary renal cell carcinoma (RCC) who have exhausted …

Oncorena is developing a first-in-class therapy for metastatic renal cancer based on orellanine, a toxin from the Cortinarius family of mushrooms. Accidental intake of such mushrooms is well …

They are among world's most poisonous mushrooms as they contain the highly toxic compound orellanine. The best-known species are the deadly webcap (Cortinarius rubellus, formerly also …

Jun 12, 2015 · Orellanine (also called orellanin) poisoning has the longest latent period of all mushroom toxins. The initial symptoms resemble the flu and appear between 12 hours and 3 …

Fungal metabolites represent an underutilized resource in the development of novel anticancer drugs. This review will focus on the promising fungal nephrotoxin orellanine, found in …

Oct 2, 2025 · Orellanine is a selective, kidney‑damaging toxin found in Cortinarius mushrooms such as the Fool’s Webcap and Deadly Webcap. Its long latency, irreversible kidney damage, …