May 16, 2024 · Mast cells are a part of your immune system. They’re made in your bone marrow, then move through your bloodstream into your tissues. The mature mast cells live in tissues throughout …

Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense …

Mast cells are long-lived tissue-resident cells with an important role in many inflammatory settings including host defence to parasitic infection and in allergic reactions.

Mar 19, 2024 · Mast cells were discovered by Paul Ehrlich in 18781 and are primarily associated with the innate immune response, a non-specific arm of the immune system. They are particularly …

Aug 5, 2025 · Mast cells act as sentinels of the immune system, constantly monitoring their environment for signs of danger. They play a part in innate immunity, the body’s first line of defense, by detecting …

Jan 30, 2025 · Mast cells are crucial components of the immune system, playing multifaceted roles in allergic reactions, pathogen defense, and inflammatory processes. Originating from bone marrow, …

Jul 1, 2022 · Mast cells are cells of the immune system of the hematopoietic lineage that remain widely distributed in vascularized tissues throughout the body. Mast cells, unlike other immune cells, do not …

Jan 6, 2016 · With respect to normal physiological functions, mast cells are known to regulate vasodilation, vascular homeostasis, innate and adaptive immune responses, angiogenesis, and …

This function highlights the dual role of mast cells as both protectors against pathogens and important contributors to recovery. In summary, the biological functions of mast cells encompass multiple roles …

In this review, we provide a comprehensive overview of the functions of MCs in health and disease. Further, we discuss how mouse models of MC deficiency have become useful tools for establishing …