The growth rate of the atmospheric abundance of methane (CH 4) reached a record high of 15.4 ppb yr −1 between 2020 and 2022, but the mechanisms driving the accelerated CH 4 growth have so far been ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

During oogenesis, maternally derived protein/mRNA (e.g. Oskar, Vasa, Aubergine, Tudor) localize to the posterior pole for the formation of the germ plasm which possess the ability to induce primordial ...

This study was supported in part by Grants-in-Aid for Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology, Japan (KAKENHI Grant No. JP16H06452 to T.D.) ...

Using novel mouse models, we establish cyclin-dependent kinase 12 (CDK12) as a bona fide tumor suppressor gene in tubo-ovarian high-grade serous carcinoma, demonstrating that its loss drives increased ...

Nav1.8 sodium channels are highly expressed in primary pain-sensing neurons. Suzetrigine is a potent and highly selective Nav1.8 inhibitor that has recently been approved by the Food and Drug ...

Green pigmentation provides a wide variety of animals with the ability to camouflage themselves among green vegetation. The molecular mechanisms of green coloration in insects are not well-understood, ...

Turbulence at centimeter scales plays a pivotal role in shaping the overturning circulation of the deep ocean (1, 2), as well as the ocean’s capacity to distribute and store climate-critical tracers ...

The fishery for Antarctic krill (Euphausia superba, hereafter referred to as “krill”) is one of the world’s largest fisheries for crustaceans (), and by far, the largest fishery in the Southern Ocean ...

To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia ...

HBx plays a pivotal role in HBV replication by enhancing cccDNA transcription. However, the HBx structure remains unsolved, representing a significant gap in knowledge. Here, we show the cryo-EM ...