Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

We demonstrate that TP53 deficiency in AML cells confers resistance to CAR T-cell therapy by inducing CAR T-cell dysfunction. We propose a model in which difficult-to-kill TP53-mutant AML cells ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

The effect of the DNMT3A R882 H mutation in a pre-leukaemic setting is not well understood. The murine homologue of the R882H mutation is R878H, and Dnmt3a R878H mouse models (Dai et al, 2017; Liao et ...

ADHD is a prevalent neurodevelopmental disorder characterized by predominant symptoms in the domains of inattention, hyperactivity, and impulsivity, either individually or combined, and primarily ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

Despite considerable advances in drug discovery, clinical success has proven challenging in preventing the spread of cancer. Tumors often recapitulate programs to acquire advantageous invasive and ...

In this context, the process of autophagy can be considered as a bona fide health‐modifying agent (Choi et al, 2013; Mizushima & Levine, 2020).Indeed, a large body of evidence from the literature ...

By reconstituting eukaryotic DNA replication in vitro, this study addresses the effects of physiological quadruplex secondary structures on genome stability.G‐quadruplexes (G4s) and intercalated ...

During human lung development, the distal tip epithelial cells act as multipotent progenitors (Nikolić et al, 2017; Miller et al, 2020).From ~15 pcw (postconception weeks) the human tips retain ...