For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these ...

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, ...

Researchers have removed mitochondria from cells to better study their functions in regulating cell death, differentiation ...

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New research published in Nature Communications into hidden mutations in mitochondrial DNA has uncovered how high mutational ...

Mitochondria have their own DNA, which consists of only 37 genes, compared with the thousands of genes in the spiraling chromosomes inside the cell nucleus.

This review focuses on the unique characteristics of mitochondrial nucleoids in mammalian cells, highlighting their semi-autonomous nature and the ...

In a mouse model, stem cells with defective mitochondria unleashed a stress response — a cascade of molecular signals that activated stress-response genes in the nucleus — and then the cells stalled ...

Oxygen reduction reaction (ORR) is the exothermic reaction in mitochondria, and ORR-driven mitochondrial thermogenesis can induce the HSF1-mediated heat shock response in the nucleus.

To perform various tasks, such as instructing the nucleus to turn on or off particular genes, proteins must enter and exit the nucleus, the cell’s control center. These proteins pass through a channel ...

Though the models agree that the mitochondrion evolved from an alphaproteobacterium, they have very different ideas about the origin of the nucleus and other organelles.