In drug development projects, evaluating drug-target residence times can enhance drug efficacy, widen the therapeutic window, and reduce the likelihood of prematurely advancing candidate compounds ...

My overall goal is to mentor a vibrant research team focused on developing new ultrafast vibrational spectroscopy techniques for investigating biological systems on the sub-micron scale. We will ...

A mutant DJ-1 gene causes recessive Parkinson's disease, but the molecular mechanism of this process has not been well studied. To understand how DJ-1 hydrolyzes cyclic 3-phosphoglyceric anhydride—a ...