A breast cancer patient in her 30s presented for assessment of disseminated erythematous papules and nodules 9 months after undergoing her final chemotherapy treatment. Her medical history showed that ...

DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrasetargeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a ...

Gepotidacin is an oral, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by blocking 2 different type II topoisomerase enzymes. Study participants were randomly ...

Gepotidacin is a first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by blocking 2 different type II topoisomerase enzymes. Oral gepotidacin was found to be ...

The novel antibiotic works by inhibiting type II topoisomerase, an enzyme crucial for bacterial function and reproduction. Treatment with oral zoliflodacin, a first-in-class spiropyrimidinetrione ...

This new article publication from Acta Pharmaceutica Sinica B, discusses discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection. The ...