Cell growth and proliferation rates depend critically upon the rate of protein synthesis. Normal cells that are able to proliferate generally do so transiently in response to appropriate extracellular ...

Eukaryotic initiation factor (eIF) 4A plays an essential role in translation initiation on most eukaryotic mRNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The ...

Cancer is the Houdini of diseases because it escapes elaborately contrived predicaments. Like Houdini, who was known to emerge triumphant after being handcuffed, locked in a trunk, and tossed into a ...

Transcription and translation are processes a cell uses to make all proteins the body needs to function from information stored in the sequence of bases in DNA. The four bases (C, A, T/U, and G in the ...

Translational control plays an important role in cell growth and tumorigenesis. Cap-dependent translation initiation of mammalian mRNAs with structured 5' UTRs requires the DExH-box protein, DHX29, in ...

ReAberrant translation initiation at non-AUG start codons is associated with cancer and neurodegenerative diseases. Therefore, identifying how non-AUG translation is regulated differently from ...