Assessment of PARP1 mRNA expression as prognostic of aggressive pathology and adverse outcomes, and as predictor of response to PARP inhibition in castration-sensitive prostate cancer. Association of ...

An international collaboration led by RIKEN researchers has discovered how unusual spherical structures form in the brains of people with a mutation that causes a form of inherited Alzheimer's disease ...

Missense mutations influence protein abundance in prostate cancer. Using a SILAC-based quantitative proteomics approach, we identified significant proteomic differences between healthy and tumor ...

Impact of Germline BRCA Mutation Status on Antitumor Activity of Modified FOLFIRINOX in Patients With Advanced Pancreatic Cancer: An Exploratory Analysis Swiss-PO was expanded and redesigned to ...

Disruptions in transcriptional regulation during hematopoiesis can lead to abnormal hematopoietic differentiation and the development of leukemia. Understanding the underlying mechanisms of disease ...

Researchers at the Institute for Bioengineering of Catalonia (IBEC) have produced a mutational map showing how mutations in ...

Targeted resequencing of DNA allows researchers to focus on genes of interest for cost-effective analysis of genetic variations. Typically, to analyze single nucleotide mutations and copy number ...

Helen Branswell covers issues broadly related to infectious diseases, including outbreaks, preparedness, research, and vaccine development. Follow her on Mastodon and Bluesky. You can reach Helen on ...