Pharmacodynamic interactions alter pharmacologic efficacy of a drug, although drug plasma levels remain unaltered. 2 This has an impact on either the pharmacologic efficacy or on the magnitude of side ...

For more than 20 years, the University of Washington has been home to a database built, maintained and expanded around the goal of helping to prevent health complications from adverse drug reactions, ...

Drug-drug interactions (DDIs) remain a critical challenge in both clinical practice and the drug discovery process, given their potential to produce unforeseen adverse effects and compromise patient ...

A recent US Food and Drug Administration (FDA) advisory committee meeting highlighted the potential of clinical pharmacology to overcome challenges in orphan drug development. There has been marked ...

Regulators, developers, and testing laboratories are exploring in silico models, transporter assays, and other options to better predict drug combination outcomes In the future, many drug–drug ...

DURHAM, N.C., June 24, 2025 (GLOBE NEWSWIRE) -- Fortrea (Nasdaq: FTRE) (the “Company”), a leading global contract research organization (CRO), today announced a strategic collaboration with Emery ...

p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma. All patients in this multicenter study were 45 years or older and had measurable residual tumor on ...

A team of mathematicians and pharmaceutical scientists collaborated to identify the major cause of the low accuracy of the equation in the FDA guidance used to predict drug-drug interaction through an ...

Q: I experienced serotonin syndrome once, even though I used a drug interaction checker. Unfortunately, it was hard to use. As a result, I had a scary experience. Being a wary person, I went to an ...

Q: I have understood that grapefruit juice generally should not be used to take medicine. My wife believes that orange juice also is dangerous. She is urging me not to take my pills with orange juice.