The nematode Caenorhabditis elegans continues to serve as an essential model for understanding germline stem cell biology. Central to this field is the precise regulation of the balance between stem ...

We used genome-wide RNA interference (RNAi) to identify genes that affect apoptosis in the C. elegans germ line. RNAi-mediated knockdown of 21 genes caused a moderate to strong increase in germ cell ...

A robotic system capable of imaging and transferring the model organism Caenorhabditis elegans could replace hours of tedious lab work, according to a recent study. Laboratory workers spend untold ...

In 1963, on a hunch, a South African biologist named Sydney Brenner decided to study a species of worms named C. elegans. The worms turned out to be the perfect lab animal. They were simple creatures ...

In the 1970s biologist Sydney Brenner and his colleagues began preserving tiny hermaphroditic roundworms known as Caenorhabditis elegans in agar and osmium fixative, slicing up their bodies like ...

The Caenorhabditis elegans germ-line development defective (GLD)-2–GLD-3 complex up-regulates the expression of genes required for meiotic progression. GLD-2–GLD-3 acts by extending the short poly(A) ...

The model will permit to accelerate and reduce the price of the research, which is studying the mechanisms and the possible pharmacological targets for the neuronal alterations of this disease. The ...

This study highlights a novel mechanism of gut-to-brain communication crucial for lipid metabolism. In a recent study published in Nature Communications, researchers identify an endogenous insulin ...

A study of nematodes by researchers at Nagoya University in Japan has found that aging-related decline in brain function is caused by the excessive activation of certain neurons over time, rather than ...