Three of C. elegans' primary regulators of apoptosis actively promote cell death, whereas just one, CED-9, reins in the apoptosis-promoting proteins to keep cells alive.

UV-C radiation induces apoptosis in the C. elegans germ line via transcriptional activation of egl-1 and ced-13.(a) Dose–response.Apoptotic germ cell corpses were scored in young adult animals ...

CPS-6 is the first mitochondrial protein identified to be involved in programmed cell death in C. elegans, underscoring the conserved and important role of mitochondria in the execution of apoptosis.

Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis. PLOS Genetics , 2018; 14 (7): e1007417 DOI: 10.1371/journal.pgen.1007417 Cite This Page : ...

image: The discovery of a novel cellular "switch" in the popular laboratory research worm, C. elegans by a University of Colorado at Boulder team may provide researchers with a new means of ...

We found that reduction of the wah-1 activity in C.elegans delays the normal progression of apoptosis, results in accumulation of TUNEL-positive DNA breaks, and enhances the defects of other cell ...

To increase the persistence of apoptotic cells, the researchers used C. elegans strains that had been rendered engulfment-defective by deletion of the transmembrane receptor gene ced-1. Since previous ...

Importantly, inactivation of the gene encoding either the C. elegans apoptosis-inducing factor (AIF) homologue (WAH-1), a mitochondrial apoptogenic factor, or the C. elegans phospholipid scramblase 1 ...

In particular, the team used C. elegans carrying a genetic mutation with a mutant allele that results in temperature-sensitive loss of the DYN-1 protein: at 25 °C, DYN-1 degrades, whereas at 15 ...

A protein's dual role. Three of C. elegans' primary regulators of apoptosis actively promote cell death, whereas just one, CED-9, reins in the apoptosis-promoting proteins to keep cells alive.

A highly detailed study of how the roundworm C. elegans forms oocytes suggests that ... a large percentage of the potential eggs get culled through a controlled demolition process called apoptosis.