Microtubules are the largest type of filament, with a diameter of about 25 nanometers (nm), and they are composed of a protein called tubulin. Actin filaments are the smallest type, with a ...

An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

Alushin's lab specializes in understanding the cytoskeleton—the network of protein filaments, including actin, that form a cell's infrastructure. Actin serves many functions: it provides cells ...

Thin, flexible protein strands called actin filaments act like bones for our cells and are critical for its movement. Supercomputer simulations have helped solve a decades-old mystery of how actin ...

The actin filament exists as a structure of the fixed length and bears the muscle contraction and the adjustment on a muscular inside. The circulation and the molecule movements of the polymerization ...

Intrigued, Tilney took on the project, and together the pair showed that after breaking out of the vacuole, Listeria managed, somehow, to construct its own tail-like structure out of actin filaments. ...

In the absence of SNX33, WAVE2 instead persisted at the site of contact, while actin filaments accumulated within the cell. These results, indicating uncontrolled actin polymerization, could explain ...

The organization and dynamics of actin filaments must be precisely controlled during these processes, and consequently defects in regulation of the actin cytoskeleton lead to various diseases ...

The actin cytoskeleton is the network of proteins bound together in filaments that determine a cell's shape and enables ...

The mechanism of molecular motors involves a cyclic interaction between the motor domain and the cytoskeletal filament (actin or microtubule). ATP hydrolysis induces conformational changes in the ...

and I hope to understand the mechanism behind the self-organization of actin cytoskeleton into functionally-distinct actin filaments in migratory human cancer cells. I love spending time with my ...